4250 Midamerica Lane, 63129 St Louis
Room descriptions from the hotel. Available rooms and prices for your dates appear above.
1 King Bed 300 sq feet Internet - Free WiFi and wired internet access Entertainment - 49-inch flat-screen TV with cable channels Food & Drink - Refrigerator, microwave, and coffee/tea maker Sleep - Blackout drapes/curtains and bed sheets Bathroom - Private bathroom, shower/tub combination, free toiletries, and a hair dryer Practical - Safe, iron/ironing board, and laptop workspace; rollaway beds (free) and cribs (free) available on request Comfort - Fresh bed sheets (on request), fresh towels (on request), and climate-controlled air conditioning Accessibility - Closed-captioned TV Need to Know - Housekeeping on request Non-Smoking Connecting/adjoining rooms can be requested, subject to availability
1 King Bed 300 sq feet Internet - Free WiFi and wired internet access Entertainment - 49-inch flat-screen TV with cable channels Food & Drink - Refrigerator, microwave, and coffee/tea maker Sleep - Blackout drapes/curtains and bed sheets Bathroom - Private bathroom, bathtub, free toiletries, and a hair dryer Practical - Safe, iron/ironing board, and laptop workspace; rollaway beds (free) and cribs (free) available on request Comfort - Fresh bed sheets (on request), fresh towels (on request), and climate-controlled air conditioning Accessibility - Wheelchair accessible Need to Know - Housekeeping on request Non-Smoking Connecting/adjoining rooms can be requested, subject to availability
2 Queen Beds 300 sq feet Internet - Free WiFi and wired internet access Entertainment - 49-inch flat-screen TV with cable channels Food & Drink - Refrigerator, microwave, and coffee/tea maker Sleep - Blackout drapes/curtains and bed sheets Bathroom - Private bathroom, shower/tub combination, free toiletries, and a hair dryer Practical - Safe, iron/ironing board, and laptop workspace; rollaway beds (free) and cribs (free) available on request Comfort - Fresh bed sheets (on request), fresh towels (on request), and climate-controlled air conditioning Accessibility - Closed-captioned TV Need to Know - Housekeeping on request Non-Smoking Connecting/adjoining rooms can be requested, subject to availability
This suite features a 49-inch HDTV, fridge and microwave. A single-cup coffee maker and work desk are available.
This suite features a 49-inch HDTV, fridge and microwave. A single-cup coffee maker and work desk are available. The bathroom comes with a walk-in shower. There is also a seating area with a sofa bed.
This suite features a 49-inch HDTV, fridge and microwave. A single-cup coffee maker and work desk are available.
This accessible room features a 49-inch HDTV, fridge and microwave. A single-cup coffee maker and work desk are available.
This room features a 49-inch HDTV, fridge and microwave. A single-cup coffee maker and work desk are available.
This room features a 49-inch HDTV, fridge and microwave. A single-cup coffee maker and work desk are available.
This accessible room features a 49-inch HDTV, fridge and microwave. A single-cup coffee maker and work desk are available.
This accessible room features a 49-inch HDTV, fridge and microwave. A single-cup coffee maker and work desk are available.
This accessible room features a 49-inch HDTV, fridge and microwave. A single-cup coffee maker and work desk are available.
Please note the room type and bed type will be allocated upon check-in. It might be a higher room category but is subject to availability upon arrival.
1 night · 1 room · 2 adults
Room details at the next step
Refundable · deadline confirmed before payment.
Meal plan confirmed at the next step.
$152 USD total · 1 night
Recorded price · confirmed again before you book.
1 night · 1 room · 2 adults
Last priced: 2 Bed Hearing Accessible Non-smoking
Non-refundable rate.
breakfast included
$130 USD total · 1 night
Recorded price · confirmed again before you book.
1 night · 1 room · 2 adults
Last priced: Two Queen Beds Non-Smoking
Refundable · deadline confirmed before payment.
breakfast included
$145 USD total · 1 night
Recorded price · confirmed again before you book.
7 nights · 1 room · 2 adults
Last priced: Two Queen Beds Non-Smoking
Non-refundable rate.
breakfast included
$1,063 USD total · 7 nights
Recorded price · confirmed again before you book.
7 nights · 1 room · 2 adults
Last priced: 2 Queen Stndrd Mobil Acc Tub
Refundable · deadline confirmed before payment.
breakfast included
$1,223 USD total · 7 nights
Recorded price · confirmed again before you book.
1 night · 1 room · 2 adults
Room details at the next step
Refundable · deadline confirmed before payment.
Meal plan confirmed at the next step.
$169 USD total · 1 night
Recorded price · confirmed again before you book.
1 night · 1 room · 2 adults
Room details at the next step
Refundable · deadline confirmed before payment.
Meal plan confirmed at the next step.
$183 USD total · 1 night
Recorded price · confirmed again before you book.
1 night · 1 room · 2 adults
Last priced: Two Queen Beds Non-Smoking
Non-refundable rate.
breakfast included
$158 USD total · 1 night
Recorded price · confirmed again before you book.
1 night · 1 room · 2 adults
Last priced: 2 Queen Stndrd Mobil Acc Tub
Refundable · deadline confirmed before payment.
breakfast included
$180 USD total · 1 night
Recorded price · confirmed again before you book.
7 nights · 1 room · 2 adults
Last priced: 2 Bed Mobility Accessible Tub Non-smoking
Non-refundable rate.
breakfast included
$964 USD total · 7 nights
Recorded price · confirmed again before you book.
7 nights · 1 room · 2 adults
Last priced: 2 Queen Stndrd Mobil Acc Tub
Refundable · deadline confirmed before payment.
breakfast included
$1,173 USD total · 7 nights
Recorded price · confirmed again before you book.
1 night · 1 room · 2 adults
Room details at the next step
Refundable · deadline confirmed before payment.
Meal plan confirmed at the next step.
$169 USD total · 1 night
Recorded price · confirmed again before you book.
1 night · 1 room · 2 adults
Room details at the next step
Refundable · deadline confirmed before payment.
Meal plan confirmed at the next step.
$164 USD total · 1 night
Recorded price · confirmed again before you book.
1 night · 1 room · 2 adults
Room details at the next step
Refundable · deadline confirmed before payment.
Meal plan confirmed at the next step.
$137 USD total · 1 night
Recorded price · confirmed again before you book.
1 night · 1 room · 2 adults
Last priced: 2 Bed Hearing Accessible Non-smoking
Non-refundable rate.
breakfast included
$139 USD total · 1 night
Recorded price · confirmed again before you book.
1 night · 1 room · 2 adults
Last priced: 2 Queen Stndrd Mobil Acc Tub
Refundable · deadline confirmed before payment.
breakfast included
$178 USD total · 1 night
Recorded price · confirmed again before you book.
7 nights · 1 room · 2 adults
Last priced: 2 Bed Mobility Accessible Tub Non-smoking
Non-refundable rate.
breakfast included
$944 USD total · 7 nights
Recorded price · confirmed again before you book.
7 nights · 1 room · 2 adults
Last priced: 2 Queen Stndrd Mobil Acc Tub
Refundable · deadline confirmed before payment.
breakfast included
$1,191 USD total · 7 nights
Recorded price · confirmed again before you book.
1 night · 1 room · 2 adults
Room details at the next step
Refundable · deadline confirmed before payment.
Meal plan confirmed at the next step.
$185 USD total · 1 night
Recorded price · confirmed again before you book.
1 night · 1 room · 2 adults
Room details at the next step
Refundable · deadline confirmed before payment.
Meal plan confirmed at the next step.
$185 USD total · 1 night
Recorded price · confirmed again before you book.
1 night · 1 room · 2 adults
Room details at the next step
Refundable · deadline confirmed before payment.
Meal plan confirmed at the next step.
$178 USD total · 1 night
Recorded price · confirmed again before you book.
1 night · 1 room · 2 adults
Room details at the next step
Refundable · deadline confirmed before payment.
Meal plan confirmed at the next step.
$172 USD total · 1 night
Recorded price · confirmed again before you book.
1 night · 1 room · 2 adults
Room details at the next step
Refundable · deadline confirmed before payment.
Meal plan confirmed at the next step.
$194 USD total · 1 night
Recorded price · confirmed again before you book.
1 night · 1 room · 2 adults
Room details at the next step
Refundable · deadline confirmed before payment.
Meal plan confirmed at the next step.
$164 USD total · 1 night
Recorded price · confirmed again before you book.
1 night · 1 room · 2 adults
Room details at the next step
Refundable · deadline confirmed before payment.
Meal plan confirmed at the next step.
$129 USD total · 1 night
Recorded price · confirmed again before you book.
1 night · 1 room · 2 adults
Room details at the next step
Refundable · deadline confirmed before payment.
Meal plan confirmed at the next step.
$188 USD total · 1 night
Recorded price · confirmed again before you book.
1 night · 1 room · 2 adults
Room details at the next step
Refundable · deadline confirmed before payment.
Meal plan confirmed at the next step.
$209 USD total · 1 night
Recorded price · confirmed again before you book.
1 night · 1 room · 2 adults
Room details at the next step
Refundable · deadline confirmed before payment.
Meal plan confirmed at the next step.
$212 USD total · 1 night
Recorded price · confirmed again before you book.
1 night · 1 room · 2 adults
Room details at the next step
Refundable · deadline confirmed before payment.
Meal plan confirmed at the next step.
$207 USD total · 1 night
Recorded price · confirmed again before you book.
1 night · 1 room · 2 adults
Room details at the next step
Refundable · deadline confirmed before payment.
Meal plan confirmed at the next step.
$175 USD total · 1 night
Recorded price · confirmed again before you book.
1 night · 1 room · 2 adults
Room details at the next step
Refundable · deadline confirmed before payment.
Meal plan confirmed at the next step.
$175 USD total · 1 night
Recorded price · confirmed again before you book.
1 night · 1 room · 2 adults
Room details at the next step
Refundable · deadline confirmed before payment.
Meal plan confirmed at the next step.
$140 USD total · 1 night
Recorded price · confirmed again before you book.
1 night · 1 room · 2 adults
Room details at the next step
Refundable · deadline confirmed before payment.
Meal plan confirmed at the next step.
$207 USD total · 1 night
Recorded price · confirmed again before you book.
1 night · 1 room · 2 adults
Room details at the next step
Refundable · deadline confirmed before payment.
Meal plan confirmed at the next step.
$207 USD total · 1 night
Recorded price · confirmed again before you book.
1 night · 1 room · 2 adults
Room details at the next step
Refundable · deadline confirmed before payment.
Meal plan confirmed at the next step.
$201 USD total · 1 night
Recorded price · confirmed again before you book.
1 night · 1 room · 2 adults
Room details at the next step
Refundable · deadline confirmed before payment.
Meal plan confirmed at the next step.
$207 USD total · 1 night
Recorded price · confirmed again before you book.
1 night · 1 room · 2 adults
Room details at the next step
Refundable · deadline confirmed before payment.
Meal plan confirmed at the next step.
$185 USD total · 1 night
Recorded price · confirmed again before you book.
1 night · 1 room · 2 adults
Room details at the next step
Refundable · deadline confirmed before payment.
Meal plan confirmed at the next step.
$207 USD total · 1 night
Recorded price · confirmed again before you book.
1 night · 1 room · 2 adults
Room details at the next step
Refundable · deadline confirmed before payment.
Meal plan confirmed at the next step.
$137 USD total · 1 night
Recorded price · confirmed again before you book.
1 night · 1 room · 2 adults
Room details at the next step
Refundable · deadline confirmed before payment.
Meal plan confirmed at the next step.
$201 USD total · 1 night
Recorded price · confirmed again before you book.
1 night · 1 room · 2 adults
Room details at the next step
Refundable · deadline confirmed before payment.
Meal plan confirmed at the next step.
$210 USD total · 1 night
Recorded price · confirmed again before you book.
1 night · 1 room · 2 adults
Room details at the next step
Refundable · deadline confirmed before payment.
Meal plan confirmed at the next step.
$207 USD total · 1 night
Recorded price · confirmed again before you book.
1 night · 1 room · 2 adults
Room details at the next step
Refundable · deadline confirmed before payment.
Meal plan confirmed at the next step.
$201 USD total · 1 night
Recorded price · confirmed again before you book.
1 night · 1 room · 2 adults
Room details at the next step
Refundable · deadline confirmed before payment.
Meal plan confirmed at the next step.
$212 USD total · 1 night
Recorded price · confirmed again before you book.
1 night · 1 room · 2 adults
Room details at the next step
Refundable · deadline confirmed before payment.
Meal plan confirmed at the next step.
$160 USD total · 1 night
Recorded price · confirmed again before you book.
1 night · 1 room · 2 adults
Room details at the next step
Refundable · deadline confirmed before payment.
Meal plan confirmed at the next step.
$137 USD total · 1 night
Recorded price · confirmed again before you book.
1 night · 1 room · 2 adults
Room details at the next step
Refundable · deadline confirmed before payment.
Meal plan confirmed at the next step.
$201 USD total · 1 night
Recorded price · confirmed again before you book.
1 night · 1 room · 2 adults
Room details at the next step
Refundable · deadline confirmed before payment.
Meal plan confirmed at the next step.
$207 USD total · 1 night
Recorded price · confirmed again before you book.
1 night · 1 room · 2 adults
Room details at the next step
Refundable · deadline confirmed before payment.
Meal plan confirmed at the next step.
$212 USD total · 1 night
Recorded price · confirmed again before you book.
1 night · 1 room · 2 adults
Room details at the next step
Refundable · deadline confirmed before payment.
Meal plan confirmed at the next step.
$216 USD total · 1 night
Recorded price · confirmed again before you book.
Review the hotel and dates in your account before starting a price watch. Weekly deal emails are optional.
Modern Amenities
Holiday Inn Express & Suites - St. Louis South - I-55 offers free WiFi, flat-screen TVs, microwaves, and desks in every room. Guests can also enjoy the convenience of a refrigerator and complimentary toiletries in the private bathrooms.
Convenient Location
Located in Mattese, our hotel is just 21 km from Saint Louis and 27 km from Chesterfield. The Lambert-St. Louis International Airport is a short 29 km drive away, making travel a breeze for our guests.
Exceptional Service
From the moment you arrive, our staff is dedicated to ensuring your stay is comfortable and memorable. Book your stay at Holiday Inn Express & Suites - St. Louis South - I-55 now for a delightful experience.
Swipe the chart to compare months →
Lower Near usual Higher12-month median $183/night
Select a month. See dated stays ↑
October 2026: $152 a night. November 2026: $159 a night. December 2026: $169 a night. January 2027: $185 a night. February 2027: $175 a night. March 2027: $199 a night. April 2027: $175 a night. May 2027: $204 a night. June 2027: $196 a night. July 2027: $204 a night. August 2027: $181 a night. September 2027: $212 a night.
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2 nights recorded so far, tracking since 16 Oct 2026 — the chart appears at 7 nights.
We have 1 night of prices for this room so far. Percentile, volatility and the refundable spread need at least 10 before they mean anything, so they are not shown yet.
| Stay | Now | Median | Low | High | Nights |
|---|---|---|---|---|---|
| 1 night, 30 days ahead, non-refundable | Now$130 | Median$130 | Low$130 | High$130 | Nights1 |
| 1 night, 30 days ahead, refundable | Now$145 | Median$146 | Low$145 | High$148 | Nights1 |
| 1 night, 60 days ahead, non-refundable | Now$158 | Median$158 | Low$158 | High$158 | Nights1 |
| 1 night, 60 days ahead, refundable | Now$180 | Median$180 | Low$180 | High$180 | Nights1 |
| 1 night, 90 days ahead, non-refundable | Now$139 | Median$139 | Low$139 | High$139 | Nights1 |
| 1 night, 90 days ahead, refundable | Now$178 | Median$178 | Low$178 | High$178 | Nights1 |
| 7 nights, 30 days ahead, non-refundable | Now$1,063 | Median$1,063 | Low$1,063 | High$1,063 | Nights1 |
| 7 nights, 30 days ahead, refundable | Now$1,223 | Median$1,223 | Low$1,223 | High$1,223 | Nights1 |
| 7 nights, 60 days ahead, non-refundable | Now$964 | Median$964 | Low$964 | High$964 | Nights1 |
| 7 nights, 60 days ahead, refundable | Now$1,173 | Median$1,173 | Low$1,173 | High$1,173 | Nights1 |
| 7 nights, 90 days ahead, non-refundable | Now$944 | Median$944 | Low$944 | High$944 | Nights1 |
| 7 nights, 90 days ahead, refundable | Now$1,191 | Median$1,191 | Low$1,191 | High$1,191 | Nights1 |
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